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Binance and MEXC each hold nearly $3B in active perp liquidity, about double any other venue. Then a sharp drop: Hyperliquid $2.09B, Gate $1.83B, and Bitget with ~$1.1B.

The story here is Hyperliquid — the only DEX near the top, beating Bybit, OKX and Bitget on active perp liquidity. On-chain perps now compete with the biggest CEXs for real depth.

Anthropic has quietly established a wet lab in the San Francisco Bay Area, moving beyond purely computational research as it expands its AI-driven life sciences program. The company says the lab will combine in-house biological experiments with work conducted by external partners.

Anthropic aims to use Claude and robotic systems to automate parts of laboratory work, while keeping human oversight in place for safety. The company is also developing tools for drug research and has acquired biotech startup Coefficient Bio, while collaborating with pharmaceutical firms including Genentech, Bristol Myers Squibb and Novo Nordisk.

The company is targeting areas that could benefit from faster preclinical research, including diseases that have historically been considered difficult or uneconomical to treat. Anthropic says it will not run clinical trials for now, keeping that part of the drug development process with pharma and biotech partners.

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Ethena Foundation and Ethena OpCo have agreed to permanently waive the lock-up on the ENA held by StablecoinX, its Nasdaq-listed treasury vehicle, with the release taking effect on October 5.

The waiver terminates a 48-month contractual lock, plus all vesting and unlocking restrictions, on StablecoinX's ENA position, aligning it with the release date the Foundation already set for other ENA holders. Going forward, StablecoinX can sell ENA to fund working capital and strategic needs, but must give the Foundation at least five business days' notice, during which the Foundation may elect to buy the tokens first at the proposed price.

Freeing a large treasury stake makes more ENA sellable into the market, a supply overhang traders will watch closely, even as the right of first refusal hands Ethena a lever to absorb sales instead of letting them hit exchanges.

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Singapore stablecoin payments firm dtcpay has extended its Series A to $25 million, after Japan's SBI Group came in as a strategic investor.

The round was led by Vertex Ventures Southeast Asia & India, which had anchored an earlier $10 million tranche, with further backing from Genedant Capital and returning investor Kwee Liong Tek. SBI Group is investing through SBI Ventures Asset and the SBI-NTU-Kyobo Digital Innovation Fund, framing the move as a strategic partnership to build a digital-asset payment corridor between Japan and Southeast Asia.

dtcpay, a licensed Major Payment Institution in Singapore, plans to use the capital to expand stablecoin settlement and merchant payments, adding a deep-pocketed Japanese backer as regional players race to wire stablecoins into everyday commerce.

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NYSE is weighing Avalanche as the settlement layer for a 24/7 onchain trading platform its parent ICE is building for tokenized securities.

The venue would list tokenized securities that trade around the clock, pairing NYSE's Pillar matching engine with onchain settlement so stocks can change hands against stablecoins at any hour. NYSE executive Michael Blaugrund said Avalanche "checks a lot of those boxes for us, so we're very engaged with the team," while framing the work as an evaluation of an alternative trading system that is still in development, with no launch date set.

A live NYSE venue settling equities on Avalanche would be one of the loudest votes of confidence yet in public-blockchain rails for regulated markets, placing a Wall Street incumbent alongside the crypto-native infrastructure it once kept at arm's length.

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Hyperliquid has switched on manual borrowing across HyperCore, its native onchain money market, with roughly $269 million in assets already drawn since the feature went live.

HyperCore runs the lending book directly inside Hyperliquid's exchange layer, not as a separate HyperEVM smart contract. Users on Portfolio Margin, the platform's most capital-efficient account type, can supply eligible assets into a reserve to earn interest and borrow stablecoin reserves against the collateral they post. Stablecoin borrow rates follow a utilization curve that holds a flat 5% floor below 80% utilization, then climbs steeply as the reserve tightens.

Folding a money market straight into the matching engine lets Hyperliquid keep lending, margin and trading under one balance, deepening its push to house more of DeFi's activity onchain without leaning on outside protocols.

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Wall Street kept walking in: S&P Global agreed to buy OpenZeppelin, the firm securing $37T in smart contracts, Deutsche Bank went live with institutional BTC/ETH custody, and Circle's Arc L1 hit mainnet; while crypto's courtroom pile grew, from DOJ charges against two Robinhood engineers to Celsius's $495M suit against BitMEX.

Five that actually mattered:

— S&P Global agrees to acquire OpenZeppelin

— Deutsche Bank launches institutional BTC and ETH custody

— Circle's Arc, its USDC-gas stablecoin L1, goes live on mainnet

— DOJ charges two Robinhood engineers over front-running

— Celsius sues BitMEX for ~$495M over wrongful crash liquidations

Arc has introduced Arc Studio, an AI coding agent that turns natural-language prompts into full-stack onchain applications, including frontend interfaces, backend logic, and smart contracts.

Studio is built around Arc and Circle’s infrastructure, with integrations for CCTP, Gateway, Wallets, and other stablecoin tools. Generated apps can be tested across nine EVM chains, including Arc, Ethereum, Base, Avalanche, Arbitrum, and Unichain, while the resulting code can be exported into developers’ own repositories.

The tool is designed for payments, swaps, wallets, bridges, lending, staking, programmable payouts, and AI agent payment flows, with integrations across protocols including Aave, Morpho, and Uniswap. Developers can also use Studio through existing workflows with tools such as Claude Code, Codex, and Cursor.

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The SEC issued an innovation exemption that permits limited onchain trading of tokenized NMS stocks, giving crypto platforms a temporary, conditional path to list and trade share tokens without full registration.

The order is part of Chair Paul Atkins' Project Crypto agenda and ships with guardrails, including exposure limits, disclosure requirements and a time-boxed sandbox, alongside a request for public comment. Tokenized shares can trade around the clock in fractional sizes, but holders receive price exposure only, without the voting or dividend rights that come with owning the underlying stock.

The move hands US crypto venues their clearest regulatory runway yet to bring equities onchain, setting up a parallel, 24/7 market for tokenized versions of Nasdaq- and NYSE-listed shares.

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